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Good morning. As we speak we now have Andrew Joseph’s dispatch from a Barcelona hospital that developed its personal CAR-T, an intriguing clue to how weight problems medication work within the (mouse) mind, and a win for toothbrushing vs. pneumonia.
Apple pauses gross sales of newest watches in patent battle
In case you had an Apple Watch in your want checklist for the vacations this yr, chances are you’ll must rethink. To adjust to an import ban from the Worldwide Commerce Fee imposed in October, Apple is pulling Apple Watches with blood oxygen-measuring capabilities — that’s, Apple Watch Sequence 9 and Apple Watch Extremely 2 — from its web site Thursday and from its shops Sunday. The ITC has dominated that Apple infringed on the patents of pulse oximeter firm Masimo. President Biden has till Dec. 25 to approve or veto the import ban, however Apple determined to pause gross sales first. Older variations of the Apple Watch that observe coronary heart fee and bodily exercise will nonetheless be out there.
Apple and Masimo have been battling over the heart beat oximeter story since 2020, with a mistrial in Could and a Masimo-requested retrial that may begin in a yr. STAT’s Lizzy Lawrence has extra.
Weight reduction medication might combat irritation within the mind, mouse examine suggests
A brand new examine in mice appears extra carefully at why new weight-loss medicines like Novo Nordisk’s Wegovy and Eli Lilly’s Zepbound work so properly — not only for attaining weight reduction, but in addition for slicing the chances of coronary heart assault and loss of life. There was a clue in that decrease cardiovascular threat: the advantages accrued earlier than weight reduction happened, seemingly from lowered irritation.
The study posted yesterday in Cell Metabolism discovered that GLP-1-based medication acted via the mind to scale back irritation all through the physique, simply earlier than the mice misplaced weight. If this discovery holds up in people, and if researchers can establish the place within the mind these reactions happen, new medication may intention at these areas, stated Daniel Drucker, senior writer of the examine. “It is a new mannequin for the anti-inflammatory actions of GLP-1 medication.” STAT’s Elaine Chen explains.
How — and why — a Spanish hospital developed its personal CAR-T
Greater than a decade in the past, a workforce of immunologists and hematologists in Barcelona, Spain, noticed the primary case experiences about CAR-T therapies, through which scientists take an individual’s personal immune cells and engineer them to root out most cancers as soon as reinfused right into a affected person’s physique. That workforce got down to construct their very own remedy, quite than depend on what would turn into brand-name medicines developed by pharma firms. The hospital-grown model gained regulatory approval below a particular European coverage and earned reimbursement from the nationwide well being system, at about one-third the checklist worth of Kymriah or Yescarta.
“It’s usually not what we do, educational establishments,” Julio Delgado, a hematologist at Hospital Clínic of Barcelona, advised STAT’s Andrew Joseph. “It’s simply that we see there are such a lot of sufferers within the European Union who don’t have entry to CAR-T cell merchandise.” Learn what’s concerned, and the place advocates and business disagree.
Who had been the worst biotech CEOs of 2023?
So if selecting yesterday’s greatest biopharma CEO of 2023 was a slam dunk for David Ricks at Eli Lilly, who will get the nod for worst from STAT’s Adam Feuerstein? That might be Pfizer CEO Albert Bourla. The reason being accountability: Strategic missteps, monetary miscalculations, and scientific setbacks have plunged Pfizer right into a deep disaster. Bourla is the person on the prime, so the duty lies with him.
However Bourla has a possibility to show Pfizer round, Adam notes. The 2024 reset ought to get an help from the $43 billion acquisition of most cancers drugmaker Seagen. In the meantime, the remainder of the checklist appears extra just like the “blockheads and scoundrels” of yesteryear, to make use of Adam’s time period, after which there’s the dumpster. Learn extra.
Debate is reignited on digital trackers in well being care
Trackers — ubiquitous bits of code invisibly embedded in most web sites — observe you wherever you go on the web. That’s why these on-point adverts seem, seemingly out of nowhere however really instantly from the pages you go to, the buttons you click on, and the kinds you fill out. The stakes are increased when that web page or button or type contain your delicate medical info.
We’ve advised you about investigations by STAT and The Markup that demonstrated how these trackers can leak delicate info, together with diagnoses and drugs, to firms like Meta and Google. Authorities regulators have stepped in, lawsuits have been filed, and well being programs and firms have responded. However one other contingent is steeling itself for a combat, arguing that regulators have overstepped their authority and hobbled important well being care infrastructure by concentrating on trackers. STAT’s Katie Palmer tells us extra.
Toothbrushing tied to decrease pneumonia charges for significantly sick hospital sufferers
Think about this: Stopping the commonest an infection sufferers choose up within the hospital could be so simple as brushing their enamel twice a day. A brand new review in JAMA Inside Medication analyzed 15 research of greater than 2,700 sufferers to conclude that hospital-acquired pneumonia charges had been decrease amongst sufferers randomly assigned to obtain each day toothbrushing, particularly in the event that they had been on ventilators to assist them breathe. These sufferers stayed on ventilators for a shorter time, left ICUs sooner, and had been much less more likely to die within the ICU than different sufferers. Size of their hospital stays and using antibiotics didn’t make a distinction.
Oral care has at all times been essential in these sufferers as a result of pneumonia has been linked to the microbes of their mouths that they breathe in. Antiseptics don’t appear to assist, so common toothbrushing was examined. “Oral hygiene may assume an indispensable function akin at hand hygiene within the prevention and management of well being care–related infections,” a companion commentary says.
What we’re studying
- Can AI allow you to die? Bloomberg
- Biden administration asks choose to toss out Humana’s Medicare Benefit audit lawsuit, STAT
- For the lonely, tech presents friendship – at a worth, Washington Post
- A giant false impression concerning the world’s biggest infectious killer, The Atlantic
- Prime Medication, Mukherjee’s Myeloid Therapeutics conflict over genome-editing deal, STAT