Air pollution exposure increases risk for Parkinson’s disease

Larger publicity to air air pollution will increase the danger for Parkinson’s illness (PD), in accordance with a examine published on-line Sept. 16 in JAMA Community Open.

Brittany Krzyzanowski, Ph.D., from the Barrow Neurological Institute in Phoenix, and colleagues assessed whether or not air air pollution is related to an elevated threat for PD and medical traits of PD. The evaluation included knowledge from 346 sufferers with PD and 4,813 matched controls taking part within the Rochester Epidemiology Challenge (1998 to 2015).

The researchers discovered that higher publicity to particulate matter with a diameter of <2.5 μm (PM_2.5) was related to elevated PD threat, and this threat was biggest for populations inside metropolitan cores (odds ratio [OR], 1.23) for the highest quintile of PM_2.5 publicity versus the underside quintile.

An elevated threat for PD was additionally seen with higher nitrogen dioxide (NO₂) publicity, when evaluating the highest quintile to the underside quintile (OR, 1.13). Publicity to air air pollution was related to an elevated threat for akinetic inflexible presentation (OR per every 1-μg/m³ improve in PM_2.5, 1.36).

Amongst people with PD solely, increased PM_2.5 publicity was related to a higher threat for creating dyskinesia (hazard ratio [HR] per 1-μg/m³ improve in PM_2.5, 1.42), as was elevated NO₂ publicity (HR per 1-μg/m³ improve in NO₂, 1.13).

“Importantly, in 2024, the U.S. Environmental Safety Company lowered the annual PM_2.5 customary from 12 μg/m³ to 9 μg/m³ as a consequence of rising proof of adverse well being results at ranges beneath the beforehand set customary,” the authors write. “Our examine not solely helps the findings that led to this variation, however means that the higher restrict must be lowered to eight μg/m³.”

One creator disclosed ties to the pharmaceutical business.

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